Performance characteristics

The system can be used for monoclonal antibody, secreted vaccine, or drug protein testing or production for adherent cell culture

★ Direct ventilation of deep microbubbles, with good oxygen transfer effect, meets the requirements of high-density cell culture

★ Ventilation and cells do not come into direct contact, reducing the damage of bubbles to cells ★ Solid flow bed culture system, the cultured cells are in a relatively static state, making difficult high-density cell culture simple and feasible

★ Adopting jacket and tank dual temperature PID control, stable temperature control and high precision ★ Deep ventilation adopts a special combination of hardware and software control to effectively prevent liquid backflow

★ In place sterilization and sampling valve group ensures safe, reliable, and convenient operation

★ The sterilization of the intake/exhaust filters can be carried out independently, meeting the requirement of replacing the filters during the cultivation process

The CO2/O2/AIR flow rate is controlled by a thermal mass flow controller to achieve automatic feedback control of gas flow rate

★ Dissolved oxygen control can use AIR/O2 or AIR/O2/N2 modes, and the dissolved oxygen control adopts a unique PID control logic for stable and accurate control

★ PH control adopts time judgment, which can avoid the mutual addition of CO2 and alkali ★ Peristaltic pump control interface, using external mobile peristaltic pump for easy replacement

★ The pipeline and framework adopt an open design, which is easy to use and maintain

★ The pipeline adopts 3A standard, which meets GMP and BPE requirements. ★ The connection of the mixing blade in the tank is sealed without dead corners and easy to clean

★ Pipeline construction is carried out in a clean room to ensure welding quality ★ Material imports and tank bottom valves can be sterilized separately

★ All pipes and three-way interfaces that are the same as those inside the tank meet 3D requirements

★ Bottom stirring magnetic drive ★ Control system adopts PLC control

★ Servo motor, high torque, stable and reliable operation

The software has powerful functions such as parameter setting, display control, parameter detection, curve analysis, storage, output printing, etc.

The system adopts electronic signatures, which comply with GMP audit requirements

Control system

The control system adopts PLC controller, with simple interface operation. On the main control interface, any parameter can be clicked to set and start/stop. User management is divided into two levels to ensure that system parameters are not arbitrarily modified. On the main interface, you can click to control any valve or instrument and switch between automatic and manual modes.

☆ Control mode of instruments/valves: Manual control mode can be selected on the main control interface - valves or instruments can be manually opened and closed for control; Or automatic control mode: PID control can be selected

☆ Dissolved oxygen control: Dissolved oxygen can be controlled by selecting AIR/O2 or AIR/O2/N2, etc. ☆ Dissolved oxygen control uses independent PID controllers for each control component, which can be flexibly configured and selected to meet the oxygen control requirements of different cultivation methods such as suspension, microcarriers, and sheet-like carriers

☆ The calculation method of dissolved oxygen adopts a combination of proprietary PID step logic and universal PID control logic. The dissolved oxygen control is stable with an error within ± 2%, providing a stable growth environment for cell culture. ☆ PH control: PH can be controlled by adding acid or alkali

☆ Weighing function: Customers can choose weighing and feeding control according to their needs ☆ Data processing function: able to display and analyze trend curves of all parameters, store, display, and analyze historical curves of all parameters

☆ Parameter calibration function: Various parameters can be easily calibrated through the parameter calibration interface. ☆ Multi user protection function: multi-level user management, password can be set, and unauthorized personnel cannot modify parameters

☆ Automatic control during the process: pH, temperature, stirring, defoaming, feeding DO， The start-up adopts a one key start function ☆ PH/DO/speed can be controlled in sections to meet different cultivation requirements

☆ Manual and automatic control of any function, with manual control taking priority over automatic, can meet specific control function requirements ☆ Electronic signature function, meeting GPMP requirements

Technical Parameter

QC Pro-40/75/150L